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- Chief Bender misses a perfect game by one walk as he leads the Philadelphia A's to a 4-0 victory over the Cleveland Naps
- Red Faber no-hits the Washington Senators on just 67 pitches as the Chicago White Sox win the game 4-1.
- The St. Louis Cardinals, lead by 2 home runs by Ducky Medwick, beat the Philadelphia Phillies by a score of 15-3.
- Sam Jones becomes the first black player to throw a no-hitter as he leads the Chicago Cubs to a 4-0 win over the Pittsburgh Pirates. He walked the bases loaded in the 9th, but was allowed to finish the game, and strikes out the final three hitters.
- A.J. Foyt won his first race in Kansas City, Missouri.
- The St. Louis Cardinals played their first game at Busch Memorial Stadium. They beat the Atlanta Braves 4-3. Braves centerfielder and number two hitter, Gary Geiger was the first to get a base hit with a single in the first inning. Felipe Alou, leading off for the Braves, hit the first and second homeruns.
- Ernie Banks hit his 500th career home run.
- The Milwaukee Brewers start a game against the Minnesota Twins. They finish the 4-3 victory in 22 innings on May 13th.
- The United States Football League (USFL) is formed.
- The New York Knicks won the first NBA Draft Lottery. They use the pick to select Patrick Ewing.
- The Milwaukee Brewers/Cleveland Indians game was called due to rain. It was the first rainout of the season after a record 458 games without one.
- Parma F.C. defeat Belgian side Royal Antwerp 3-1 to capture the UEFA Cup Winners' Cup at Wembley Stadium in London, England.
- Lance Armstrong became the first cyclist to repeat in the American Tour DuPont.
- Larry Bird, in his first year as the coach of the Indiana Pacers, was named the NBA Coach of the year. He was just the third rookie head coach to win the award.
- The Atlanta Braves tied a NL record when they hit a home run in their 24th straight game.
- Mark McGwire's 527 foot home run was the longest in Busch Stadium history.
- St. Louis Cardinals manager, Tony LaRussa, recorded his 1500th victory.
- Carlos Delgado passes Joe Carter as the all-time Toronto Blue Jays home run hitter with his 204th for the Jays.
- Every starter for the San Diego Padres reach base via a walk or a HBP as A.J. Burnett, of the Florida Marlins throws a no-hitter. Burnett would also double in the game. The Marlins went on to win 3-0.
- Pedro Martinez strikes out 15 Baltimore Orioles as the Boston Red Sox beat the O's, 9-0. Martinez went the entire game allowing only 2 hits. He struck out 17 in his previous start and his 32 K's in consecutive starts ties an AL record.
- Alex Cora of the Los Angeles Dodgers fouls off 14 consecutive pitches before hitting a home run on the 18th pitch thrown to him by Chicago Cubs' hurler, Matt Clement.
- Cole Hamels made his MLB debut for the Philadelphia Phillies. He one-hit the Cincinnati Reds over 5 scoreless innings as the Philles went on to win the game, 8-4.