Against the Dolphins, the Jaguars made their Wild Card chances even more trembling with Sunday's home loss.

The Colts already set an NFL record last week with their 22nd consecutive regular-season victory. If they cannot beat Miami, then how are they going to slow the Colts?

Thursday Night Football Prediction: Colts, 24-14

At 8:20 PM ET, when the Jacksonville Jaguars host the perfect Indianapolis Colts at 8:20 PM ET, NFL Thursday night football will feature one of the NFL's two undefeated teams trying to keep their perfect ledger intact.

Indianapolis Colts beat the Jacksonville Jaguars 14-12 in the teams' Sept. 13 opener, and the Colts are 12-4 against the Jaguars with Peyton Manning at quarterback.

The three-time league MVP, 28-of-38 for 301 yards with a touchdown and an interception in the September meeting, passed for 4,354 yards with 30 TD's and 11 picks in those 16 games.

Indianapolis (13-0) is coming off a 28-16 win over the Denver Broncos as -6.5 home favorites. Jacksonville (7-6) dropped a close game to Miami 10-14 as -3 home favorites but they are still mathematically alive for the playoffs.

The unbeaten Indianapolis Colts have very little at stake over the next three weeks because they have already wrapped up the AFC's No. 1 seed for the playoffs.

Jim Caldwell, the Colts' head coach, insists that finishing the regular season undefeated is not important. He plans to play his starters Thursday night against a Jacksonville Jaguars team that likely needs to win its final three games to make the postseason. Unlike the Indianapolis Colts, the Jaguars (7-6) have plenty riding on their three remaining games.

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