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- Sammy Sosa and Rafael Palmeiro take the field as the first pair of teammates to have at least 500 career home runs apiece. At the time Sosa had 574 and Palmeiro had 551.
- Mark Buehrle yields two hits in eight shutout innings and Shingo Takatsuworks a perfect ninth inning as the Chicago White Sox defeat the Cleveland Indians 1-0 in a game that takes only an hour and 51 minutes to complete. Indians pitcher Jake Westbrook allows only one run and four hits in going the distance, but it isn't good enough to win. The game's only run comes in the seventh inning on an error by Cleveland shortstop Jhonny Peralta.
- Center fielder Brad Wilkerson has the honor of being the first batter for the Washington Nationals, and he promptly responds with the first hit in Nationals history. Nevertheless, Kenny Lofton hits a three-run homer and Jon Lieber pitches 5 2/3 effective innings, leading the home team Philadelphia Phillies to an 8-4 victory over the Nationals.