AFL has a number of references:
- Alliance Football League — a semi-professional American football league.
- American Football League — a professional American football league that operated from 1960 to 1969 prior to merging with the National Football League.
- Arena Football League — an American football indoor league.
Australian rules football
- Australian Football League — the elite, professional competition in Australian rules football (formerly known as the VFL).
- Alberton Football League — Competition in Australian rules football.
- Anti-Football League — a comedic organisation (est. 1967) poking fun at Australian rules football.
- Alberta Football League — a semi-professional Canadian football competition.