List of players with the highest K/9 for the 1906 baseball season
| Rank | Player Name | K/9 |
| 1 | Red Ames | 6.913 |
| 2 | Fred Beebe | 6.685 |
| 3 | Rube Waddell | 6.481 |
| 4 | Chief Bender | 6.010 |
| 5 | Ed Walsh | 5.534 |
| 6 | Jack Pfiester | 5.504 |
| 7 | Cy Falkenberg | 5.372 |
| 8 | Orval Overall | 5.055 |
| 9 | Jack Powell | 4.869 |
| 10 | Johnny Lush | 4.836 |
| 11 | Big Jeff Pfeffer | 4.707 |
| 12 | Jack Coombs | 4.682 |
| 13 | Mordecai Brown | 4.677 |
| 14 | Bill Hogg | 4.675 |
| 15 | Eddie Plank | 4.602 |
| 16 | Harry Howell | 4.562 |
| 17 | Bob Ewing | 4.544 |
| 18 | Hooks Wiltse | 4.516 |
| 19 | Otto Hess | 4.511 |
| 20 | Jimmy Dygert | 4.475 |
| 21 | Carl Lundgren | 4.474 |
| 22 | Cy Young | 4.387 |
| 23 | Christy Mathewson | 4.328 |
| 24 | Jack Chesbro | 4.209 |
| 25 | Jake Weimer | 4.172 |
