List of players with the most runs scored during the 1906 baseball season
| Rank | Player Name | Total Rs |
| 1 | Frank Chance | 103 |
| 1 | Honus Wagner | 103 |
| 3 | Elmer Flick | 98 |
| 4 | Topsy Hartsel | 96 |
| 4 | Willie Keeler | 96 |
| 6 | Harry Davis | 94 |
| 7 | George Stone | 91 |
| 8 | Charlie Hemphill | 90 |
| 8 | Jimmy Sheckard | 90 |
| 10 | Nap Lajoie | 88 |
| 11 | Terry Turner | 85 |
| 12 | Hal Chase | 84 |
| 13 | Ed Hahn | 82 |
| 13 | Jim Nealon | 82 |
| 15 | Harry Steinfeldt | 81 |
| 15 | Miller Huggins | 81 |
| 15 | Roy Thomas | 81 |
| 18 | Ed Hahn | 80 |
| 19 | Spike Shannon | 78 |
| 20 | Fielder Jones | 77 |
| 20 | Frank Schulte | 77 |
| 20 | Sherry Magee | 77 |
| 23 | Art Devlin | 76 |
| 24 | Joe Tinker | 75 |
| 25 | Harry Lumley | 72 |
