List of players with the lowest earned run average for the 1906 baseball season
| Rank | Player Name | ERA |
| 1 | Mordecai Brown | 1.04 |
| 2 | Jack Pfiester | 1.51 |
| 3 | Doc White | 1.52 |
| 4 | Barney Pelty | 1.59 |
| 5 | Ed Reulbach | 1.65 |
| 6 | Addie Joss | 1.72 |
| 7 | Vic Willis | 1.73 |
| 8 | Jack Powell | 1.77 |
| 9 | Bob Rhoads | 1.80 |
| 10 | Otto Hess | 1.83 |
| 11 | Lefty Leifield | 1.87 |
| 12 | Ed Walsh | 1.88 |
| 13 | Jack Taylor | 1.99 |
| 14 | Nick Altrock | 2.06 |
| 15 | Harry Howell | 2.11 |
| 16 | Tully Sparks | 2.16 |
| 17 | Casey Patten | 2.17 |
| 18 | Dummy Taylor | 2.20 |
| 19 | Rube Waddell | 2.21 |
| 19 | Carl Lundgren | 2.21 |
| 21 | Jake Weimer | 2.22 |
| 22 | Bill Duggleby | 2.25 |
| 22 | Joe McGinnity | 2.25 |
| 22 | Eddie Plank | 2.25 |
| 25 | Hooks Wiltse | 2.27 |
