List of players with the highest winning percentage for the 1906 baseball season
| Rank | Player Name | W% |
| 1 | Ed Reulbach | .826 |
| 2 | Mordecai Brown | .813 |
| 3 | Eddie Plank | .760 |
| 4 | Sam Leever | .759 |
| 5 | Doc White | .750 |
| 6 | Carl Lundgren | .739 |
| 7 | Jack Pfiester | .714 |
| 8 | Addie Joss | .700 |
| 9 | Joe McGinnity | .692 |
| 10 | Bob Rhoads | .688 |
| 11 | Orval Overall | .667 |
| 12 | Dummy Taylor | .654 |
| 13 | Christy Mathewson | .647 |
| 14 | Vic Willis | .639 |
| 15 | Frank Owen | .629 |
| 16 | Jack Taylor | .625 |
| 17 | Al Orth | .614 |
| 18 | Nick Altrock | .606 |
| 19 | Chief Bender | .600 |
| 19 | Deacon Phillippe | .600 |
| 19 | Fred Beebe | .600 |
| 22 | Hooks Wiltse | .593 |
| 22 | Barney Pelty | .593 |
| 24 | Jake Weimer | .588 |
| 25 | Lefty Leifield | .581 |
