List of pitchers with the most strikeouts during the 1906 baseball season
| Rank | Player Name | Total SOs |
| 1 | Rube Waddell | 196 |
| 2 | Cy Falkenberg | 178 |
| 3 | Ed Walsh | 171 |
| 3 | Fred Beebe | 171 |
| 5 | Otto Hess | 167 |
| 6 | Chief Bender | 159 |
| 7 | Big Jeff Pfeffer | 158 |
| 8 | Red Ames | 156 |
| 9 | Jack Pfiester | 153 |
| 10 | Jack Chesbro | 152 |
| 11 | Irv Young | 151 |
| 11 | Johnny Lush | 151 |
| 13 | Bob Ewing | 145 |
| 14 | Mordecai Brown | 144 |
| 15 | Jake Weimer | 141 |
| 16 | Cy Young | 140 |
| 16 | Harry Howell | 140 |
| 18 | Al Orth | 133 |
| 19 | Jack Powell | 132 |
| 20 | Christy Mathewson | 128 |
| 21 | Orval Overall | 127 |
| 22 | Hooks Wiltse | 125 |
| 23 | Vic Willis | 124 |
| 24 | George Mullin | 123 |
| 25 | Harry McIntire | 121 |
