List of pitchers with the most losses during the 1906 baseball season
| Rank | Player Name | Total Ls |
| 1 | Gus Dorner | 26 |
| 2 | Gus Dorner | 25 |
| 2 | Irv Young | 25 |
| 4 | Vive Lindaman | 23 |
| 5 | Big Jeff Pfeffer | 22 |
| 6 | Cy Young | 21 |
| 6 | Harry McIntire | 21 |
| 6 | Joe Harris | 21 |
| 9 | Chick Fraser | 20 |
| 9 | Cy Falkenberg | 20 |
| 11 | Bill Dinneen | 19 |
| 11 | Bill Duggleby | 19 |
| 11 | Ed Karger | 19 |
| 14 | Elmer Stricklett | 18 |
| 14 | George Mullin | 18 |
| 14 | George Winter | 18 |
| 17 | Al Orth | 17 |
| 17 | Jack Chesbro | 17 |
| 17 | Mal Eason | 17 |
| 17 | Otto Hess | 17 |
| 17 | Rube Waddell | 17 |
| 17 | Tom Hughes | 17 |
| 23 | Bob Wicker | 16 |
| 23 | Buster Brown | 16 |
| 23 | Casey Patten | 16 |
