List of pitchers with the most innings pitched during the 1906 baseball season
| Rank | Player Name | Total IPs |
| 1 | Irv Young | 358 |
| 2 | Joe McGinnity | 339 |
| 3 | Al Orth | 338 |
| 4 | Otto Hess | 333 |
| 5 | George Mullin | 330 |
| 6 | Jack Chesbro | 325 |
| 7 | Vic Willis | 322 |
| 8 | Tully Sparks | 316 |
| 9 | Bob Rhoads | 315 |
| 10 | Vive Lindaman | 307 |
| 11 | Jake Weimer | 304 |
| 12 | Big Jeff Pfeffer | 302 |
| 12 | Jack Taylor | 302 |
| 14 | Cy Falkenberg | 298 |
| 15 | Frank Owen | 293 |
| 16 | Elmer Stricklett | 291 |
| 17 | Gus Dorner | 288 |
| 18 | Doc Scanlan | 288 |
| 19 | Bob Ewing | 287 |
| 19 | Cy Young | 287 |
| 19 | Nick Altrock | 287 |
| 22 | Casey Patten | 282 |
| 23 | Addie Joss | 282 |
| 24 | Johnny Lush | 281 |
| 25 | Bill Duggleby | 280 |
