List of pitchers with the most games during the 1906 baseball season
| Rank | Player Name | Total Gs |
| 1 | Jack Chesbro | 49 |
| 2 | Al Orth | 45 |
| 2 | Joe McGinnity | 45 |
| 4 | Irv Young | 43 |
| 4 | Otto Hess | 43 |
| 4 | Rube Waddell | 43 |
| 7 | Bill Duggleby | 42 |
| 7 | Frank Owen | 42 |
| 7 | Tully Sparks | 42 |
| 10 | Ed Walsh | 41 |
| 10 | Elmer Stricklett | 41 |
| 10 | Jake Weimer | 41 |
| 10 | Vic Willis | 41 |
| 14 | Cy Falkenberg | 40 |
| 14 | George Mullin | 40 |
| 16 | Cy Young | 39 |
| 16 | Harry McIntire | 39 |
| 16 | Vive Lindaman | 39 |
| 19 | Bob Rhoads | 38 |
| 19 | Casey Patten | 38 |
| 19 | Christy Mathewson | 38 |
| 19 | Doc Scanlan | 38 |
| 19 | Hooks Wiltse | 38 |
| 19 | Nick Altrock | 38 |
| 25 | Johnny Lush | 37 |
