List of St. Louis Cardinals pitchers with the most saves
| Rank | Player Name | SVs |
| 1 | Jason Isringhausen | 173 |
| 2 | Lee Smith | 160 |
| 3 | Todd Worrell | 129 |
| 4 | Bruce Sutter | 127 |
| 5 | Dennis Eckersley | 66 |
| 6 | Lindy McDaniel | 64 |
| 7 | Joe Hoerner | 60 |
| 7 | Al Brazle | 60 |
| 9 | Al Hrabosky | 59 |
| 10 | Dave Veres | 48 |
| 11 | Ken Dayley | 39 |
| 12 | Tom Henke | 36 |
| 13 | Dizzy Dean | 30 |
| 14 | Ted Wilks | 29 |
| 15 | Mark Littell | 28 |
| 16 | Diego Segui | 26 |
| 16 | Slim Sallee | 26 |
| 18 | Bill Sherdel | 25 |
| 19 | Steve Kline | 21 |
| 19 | Barney Schultz | 21 |
| 19 | Hal Woodeshick | 21 |
| 22 | Larry Jackson | 20 |
| 22 | Mike Perez | 20 |
| 22 | Ricky Bottalico | 20 |
| 22 | Jeff Lahti | 20 |
