List of San Diego Padres pitchers with the most saves
| Rank | Player Name | SVs |
| 1 | Trevor Hoffman | 480 |
| 2 | Rollie Fingers | 108 |
| 3 | Rich Gossage | 83 |
| 4 | Mark Davis | 78 |
| 5 | Craig Lefferts | 64 |
| 6 | Gary Lucas | 49 |
| 7 | Randy Myers | 38 |
| 8 | Lance McCullers | 36 |
| 9 | Luis DeLeon | 31 |
| 10 | Gene Harris | 23 |
| 11 | Rod Beck | 20 |
| 12 | Butch Metzger | 16 |
| 12 | Vicente Romo | 16 |
| 14 | Larry Andersen | 15 |
| 14 | Greg Harris | 15 |
| 16 | Bill Greif | 13 |
| 16 | John D'Acquisto | 13 |
| 18 | Bob Shirley | 12 |
| 18 | Mike Caldwell | 12 |
| 20 | Tom Dukes | 11 |
| 21 | Mike Maddux | 10 |
| 21 | Dave Dravecky | 10 |
| 23 | Ron Herbel | 9 |
| 23 | Mike Corkins | 9 |
| 23 | Al Severinsen | 9 |
