List of Houston Astros pitchers with the most saves
| Rank | Player Name | SVs |
| 1 | Billy Wagner | 225 |
| 2 | Dave Smith | 199 |
| 3 | Brad Lidge | 104 |
| 4 | Fred Gladding | 76 |
| 5 | Joe Sambito | 72 |
| 6 | Doug Jones | 62 |
| 7 | Ken Forsch | 50 |
| 8 | Frank DiPino | 43 |
| 9 | Octavio Dotel | 42 |
| 10 | Todd Jones | 39 |
| 11 | Hal Woodeshick | 36 |
| 12 | John Hudek | 29 |
| 13 | Claude Raymond | 26 |
| 13 | Frank LaCorte | 26 |
| 15 | Xavier Hernandez | 25 |
| 16 | Jim Ray | 23 |
| 17 | Bill Dawley | 21 |
| 18 | Larry Andersen | 20 |
| 19 | Jim Owens | 16 |
| 20 | Al Osuna | 14 |
| 21 | Don McMahon | 13 |
| 22 | Danny Darwin | 12 |
| 22 | Dan Wheeler | 12 |
| 22 | George Culver | 12 |
| 25 | Juan Agosto | 11 |
