List of Chicago White Sox pitchers with the most saves
| Rank | Player Name | SVs |
| 1 | Bobby Thigpen | 201 |
| 2 | Roberto Hernandez | 161 |
| 3 | Keith Foulke | 100 |
| 4 | Hoyt Wilhelm | 98 |
| 5 | Terry Forster | 75 |
| 6 | Wilbur Wood | 57 |
| 7 | Bob James | 56 |
| 8 | Ed Farmer | 54 |
| 9 | Clint Brown | 53 |
| 10 | Bob Howry | 49 |
| 11 | Bob Locker | 48 |
| 12 | Bobby Jenks | 47 |
| 13 | Turk Lown | 45 |
| 14 | Eddie Fisher | 44 |
| 15 | Lerrin LaGrow | 42 |
| 16 | Gerry Staley | 39 |
| 17 | Fritz Dorish | 36 |
| 18 | Ed Walsh | 34 |
| 18 | Dustin Hermanson | 34 |
| 18 | Salome Barojas | 34 |
| 21 | Gordon Maltzberger | 33 |
| 22 | Scott Radinsky | 32 |
| 23 | Damaso Marte | 31 |
| 24 | Rich Gossage | 30 |
| 25 | Red Faber | 28 |
