List of Baltimore Orioles pitchers with the most strikeouts
| Rank | Player Name | SOs |
| 1 | Jim Palmer | 2,212 |
| 2 | Mike Mussina | 1,535 |
| 3 | Dave McNally | 1,476 |
| 4 | Mike Flanagan | 1,297 |
| 5 | Mike Cuellar | 1,011 |
| 6 | Milt Pappas | 944 |
| 7 | Steve Barber | 918 |
| 8 | Scott McGregor | 904 |
| 9 | Jack Powell | 884 |
| 10 | Dennis Martinez | 858 |
| 11 | Mike Boddicker | 836 |
| 11 | Sidney Ponson | 836 |
| 13 | Harry Howell | 712 |
| 14 | Urban Shocker | 704 |
| 15 | Scott Erickson | 699 |
| 16 | Barney Pelty | 678 |
| 17 | Ben McDonald | 638 |
| 18 | Rodrigo Lopez | 614 |
| 19 | Tippy Martinez | 585 |
| 20 | Arthur Rhodes | 579 |
| 21 | Tom Phoebus | 578 |
| 22 | Storm Davis | 539 |
| 23 | Carl Weilman | 536 |
| 24 | George Blaeholder | 520 |
| 25 | Chuck Estrada | 517 |
