List of Baltimore Orioles pitchers with the most losses
| Rank | Player Name | Ls |
| 1 | Jim Palmer | 152 |
| 2 | Jack Powell | 143 |
| 3 | Mike Flanagan | 116 |
| 4 | Dave McNally | 113 |
| 4 | Barney Pelty | 113 |
| 6 | George Blaeholder | 111 |
| 7 | Scott McGregor | 108 |
| 8 | Carl Weilman | 95 |
| 9 | Dennis Martinez | 93 |
| 10 | Harry Howell | 91 |
| 10 | Elam Vangilder | 91 |
| 12 | Earl Hamilton | 89 |
| 13 | Mike Cuellar | 88 |
| 14 | Sidney Ponson | 85 |
| 15 | Sam Gray | 82 |
| 16 | Mike Mussina | 81 |
| 16 | Jack Kramer | 81 |
| 18 | Urban Shocker | 80 |
| 19 | Steve Barber | 75 |
| 20 | Lefty Stewart | 74 |
| 20 | Milt Pappas | 74 |
| 22 | Mike Boddicker | 73 |
| 23 | Scott Erickson | 68 |
| 23 | Dixie Davis | 68 |
| 23 | Ned Garver | 68 |
