List of Arizona Diamondbacks pitchers with the most strikeouts
| Rank | Player Name | SOs |
| 1 | Randy Johnson | 1,832 |
| 2 | Curt Schilling | 875 |
| 3 | Brandon Webb | 686 |
| 4 | Miguel Batista | 454 |
| 5 | Brian Anderson | 410 |
| 6 | Byung-Hyun Kim | 380 |
| 7 | Omar Daal | 325 |
| 8 | Andy Benes | 305 |
| 9 | Jose Valverde | 253 |
| 10 | Matt Mantei | 221 |
| 11 | Claudio Vargas | 213 |
| 12 | Javier Vazquez | 192 |
| 13 | Armando Reynoso | 185 |
| 14 | Greg Swindell | 180 |
| 15 | Mike Koplove | 171 |
| 16 | Elmer Dessens | 168 |
| 17 | Todd Stottlemyre | 162 |
| 18 | Rick Helling | 120 |
| 19 | Casey Fossum | 117 |
| 20 | Steve Randolph | 112 |
| 21 | Greg Aquino | 111 |
| 22 | Russ Springer | 108 |
| 23 | Oscar Villarreal | 102 |
| 24 | Gregg Olson | 100 |
| 25 | Mike Morgan | 93 |
