List of Arizona Diamondbacks pitchers with the most runs allowed
| Rank | Player Name | Rs |
| 1 | Randy Johnson | 476 |
| 2 | Brian Anderson | 458 |
| 3 | Brandon Webb | 365 |
| 4 | Miguel Batista | 357 |
| 5 | Curt Schilling | 280 |
| 6 | Omar Daal | 240 |
| 7 | Andy Benes | 228 |
| 8 | Armando Reynoso | 226 |
| 9 | Claudio Vargas | 167 |
| 10 | Elmer Dessens | 161 |
| 11 | Byung-Hyun Kim | 123 |
| 11 | Todd Stottlemyre | 123 |
| 13 | Mike Koplove | 116 |
| 14 | Russ Ortiz | 113 |
| 15 | Javier Vazquez | 112 |
| 16 | Casey Fossum | 111 |
| 17 | Brad Halsey | 101 |
| 18 | Greg Swindell | 98 |
| 19 | Mike Morgan | 97 |
| 20 | Rick Helling | 94 |
| 21 | Lance Cormier | 92 |
| 22 | Willie Blair | 91 |
| 23 | Steve Sparks | 89 |
| 24 | Jose Valverde | 84 |
| 24 | Steve Randolph | 84 |
