List of Arizona Diamondbacks pitchers with the most losses
| Rank | Player Name | Ls |
| 1 | Randy Johnson | 49 |
| 2 | Brandon Webb | 45 |
| 3 | Brian Anderson | 42 |
| 4 | Miguel Batista | 34 |
| 5 | Omar Daal | 31 |
| 6 | Curt Schilling | 28 |
| 7 | Andy Benes | 25 |
| 8 | Armando Reynoso | 24 |
| 9 | Byung-Hyun Kim | 22 |
| 10 | Russ Ortiz | 16 |
| 10 | Claudio Vargas | 16 |
| 12 | Javier Vazquez | 15 |
| 12 | Willie Blair | 15 |
| 12 | Casey Fossum | 15 |
| 15 | Edgar Gonzalez | 14 |
| 15 | Elmer Dessens | 14 |
| 15 | Greg Swindell | 14 |
| 18 | Brad Halsey | 12 |
| 18 | Rick Helling | 12 |
| 20 | Todd Stottlemyre | 11 |
| 20 | Matt Mantei | 11 |
| 22 | Jose Valverde | 10 |
| 23 | Amaury Telemaco | 9 |
| 23 | Oscar Villarreal | 9 |
| 25 | Shawn Estes | 8 |
